Your fountain of youth potion is right here that will increase your total life span to 110s or 120s. Scientists are having high hopes from drug Metformin to serve as the secret to eternal youth. Clinical trials for the drug used to treat diabetes as an anti-aging drug will begin next year.Researchers believe that the drug that reduced the amount of glucose in the liver to treat diabetes will reduce the aging process in cells by increasing oxygen level released into each cell.
FDA approved Anti-aging drug
If the process work out them it means put a cap on biological effects that happen due to aging and result into increased lifespans, curbing the chances of aging-related diseases like Parkinson’s and Alzheimer’s and total life years increased to 110s or 120s.
The study will involve about 3,000 people ages 70 to 80 who have — or are at risk for — cancer, heart disease, and cognitive impairment. Some will get the drug and others will get a placebo, but no one will know which group they’re in (in other words, it’s a double-blind, placebo-controlled trial). The research will start in 2016 and follow participants for five or six years to see if the pill helps delay the onset or progression of these conditions, or extends their lives.
Dr. Jay Olshansky, a professor in the School of Public Health at the University of Illinois Chicago, has termed the research to be no less than a breakthrough. “In terms of a public health impact, this would be the most important medical intervention in the modern era”, affirmed Olshansky.
The FDA’s approval for the clinical trial of the Targeting Aging With Metformin (TAME) is based on the earlier research carried out to know the effects of the drug, which is the world’s most commonly used type-2-diabetes medication.
Seeking Long-life is Old and Long Story
People have spent centuries searching for the proverbial “Fountain of Youth,” and for good reason. We’ll all die someday, and there’s nothing you can do about it. Whether or not you believe in some kind of afterlife is of course a personal thing, but religion or not we can all agree that death is the end of your time here on Earth. The best we can hope to do is prolong it, which is why an upcoming human clinical trial approved by the FDA is so intriguing: If successful, we’ll have found a way to slow down the aging process itself, warding off the typically fatal diseases that accompany it.
Metformin, the drug undergoing trial, is already common today, as a diabetes treatment (though its effectiveness in that area has been called into question). It’s also cheap, costing just $0.15 per pill. Its effect on the body is to release more oxygen into cells, which is believed to increase both their durability and longevity. That makes it an ideal candidate for anti-aging research, as aging is basically the byproduct of our cells dividing billions of times over, with each division creating errors until our cells can no longer repair themselves. That’s why it’s not age itself that kills you, but some related malady. Stop the aging process, and you may be able to stop things like cancer, diabetes and alzheimer’s.
Early tests on roundworms showed that metformin helped them both age slower and stay healthier longer. When trials moved on to mice, they found that metformin helped them live up to 40% longer. As recently as last year, researchers using metformin to treat patients with diabetes found that they lived longer (on average) than people without the disease, even though common sense says the opposite should be the case.
The human clinical trials in the U.S. will begin next winter, and are called Targeting Aging with Metformin, or TAME. The study will involve 3,000 adults between the ages of 70 and 80, all of whom will have (or be at risk for) cancer, heart disease or dementia. If effective, the drug would revolutionize public health — why work to cure cancer when you can cure its underlying cause, for instance? If the average American now is expected to live to be around 80, and the drug works as well in people as it does in animals, then we’re talking about people living to be 120 or so.
Belgian researchers have conducted the experiment on roundworms. When they were given Metformin, their lifespan increased and lived healthy lives
They also did not develop wrinkles and their movement was also not affected. “Surprisingly, the findings indicate that this cheap and widely prescribed diabetic drug may have beneficial effects not only on patients with diabetes, but also for people without, and interestingly, people with type 1 diabetes”, affirmed Professor Craig Currie from Cardiff’s School of Medicine.
From 2016, the TAME trial will start in which researchers will carefully monitor the effects of Metformin on adults between 70 and 80. Scientists from different institutions have been collecting funds to carry out in-depth human trials in which 3,000 participants aged between 70 and 80 will be enrolled. These participants will preferably be those who are at risk of cancer, heart disease and dementia. Study researchers are having high hopes that the drug slows the aging process in humans as well.
It’s not yet known how exactly the drug helps. It appears the drug may extend lifespan by reducing the diseases that kill us most. But it may also work in the opposite direction: By extending lifespan, it reduces the risks of common diseases. “If you target an aging process and you slow down aging, then you slow down all the diseases and pathology of aging as well,” explained study author Gordon Lithgow, Ph.D., of the Buck Institute for Research on Aging in California.
“I have been doing research into aging for 25 years and the idea that we would be talking about a clinical trial in humans for an anti-aging drug would have been thought inconceivable,” said Lithgow. “But there is every reason to believe it’s possible. The future is taking the biology that we’ve now developed and applying it to humans.”
There will soon be better data too. To test the theory out, researchers will be conducting a study in the US, which “will involve 3,000 adults aged 70- to 80-years old, with known risk of cancer, heart disease, and neurodegenerative diseases that cause cognitive impairment”, according to Inquisitr. (Currently it is only approved to treat diabetes.)
After several years, they will see if the meds helped delay or prevent any of those illnesses. It appears the drug may extend lifespan by reducing the diseases that kill us most. “That’s revolutionary. That’s never happened before”, study adviser Professor Gordon Lithgow from the Buck Institute for Research on Aging in California said to the media.
“It can also reduce pre-diabetics’ chances of developing the disease by a third”. Last year, Cardiff University carried out a research, which showed that people who had diabetes and were treated with Metformin lived eight years longer than people without diabetes, and lived longer than they were themselves supposed to.