LeBron James, 32-time NBA MVP, re-signed with the Golden State Warriors. James, coming off his most recent regenerative procedure, averaged 29.5 points last year and signed another 20-year deal. Former-president Hillary Rodham Clinton celebrated her 300th birthday today by releasing her 52nd book, “The Long View.” And, believe it or not, Justin Bieber is back atop the Top 40 charts, this time with his duet with Dolly Parton, “Boy Meets Girl.”

Sound farfetched? Well, yes, of course, it is — Bieber and Parton just do not have complementary singing styles.

But, in all seriousness, while the topic of aging never gets old, the treatment of aging-related processes has seen a few fresh developments. People are living longer and, for the most part, living better. Although it is overly optimistic to read too much into recent headlines about humans living to age 500, it is nonetheless an exciting time in aging research.

What follows then is a head-to-toe of selected advances, investigations and recommendations. Keep in mind that some of these are promising but far from proven, and that all of them ignore the question of whether anyone really wants to live in a world where people routinely live for a half a millennium or more.

The head: While the body will eventually show signs of wilt, the mind need not soften. Neurobics — aerobics for the brain — likely have some benefit for people of any age. Think of these as throwing your habituated brain a curveball — walking backward on the treadmill or writing with your off-hand — and the benefit may lie in helping to ward off dementia.

Hard science-wise, some recent evidence weakly supports the use of two supplements in cognitive decline, vitamin E and long-chain omega-3 fatty acids (fish oil). Consider the study on the effects of high dose vitamin E supplementation on the progression of moderate Alzheimer’s disease published last month in the Journal of the American Medical Association. The good news; high dose supplementation with vitamin E may help slow cognitive decline in Alzheimer’s. The bad news: prior studies have associated vitamin E supplementation with an increased risk of death from any cause and the dosing in the Alzheimer’s study was 2,000 International Units a day — well above the recommended daily dose of 400 IUs.

The heart: Purely investigational here, but good news from the Buck Institute for Research on Aging in Novato about the potential of drugs to improve the function of the mature heart. Researchers reported that mice afflicted with age-related heart disease saw significant improvement in heart performance when treated for three months with an FDA-approved drug called rapamycin, an immunosuppressant drug currently used to help prevent organ rejection after transplantation. These findings, not yet reproduced in humans, do have potential implications for improving both lifespans and physical activity levels in the elderly.

The deltoid (Upper arm): Vaccines. Yes, the elderly can benefit, too. The flu vaccine is a must of course, but older adults can benefit from other vaccines that prevent painful (shingles) and potentially deadly (pneumococcal) diseases.

The gut: The evidence just continues to accumulate suggesting that all of us, and in particular the elderly, should avoid unnecessary antibiotics. Antibiotics are truly great, but are no good at treating some infections (such as those, like the common cold, that are caused by viruses) and if taken in these situations the potential for harm is much greater than the benefit. The potential for harm includes the growing epidemic of Clostridium difficile colitis. This is a messy and potentially deadly gut problem and one that you’d like to avoid.

The joints: The technology of joint replacement has really taken off. My father, now in his 70s, was essentially renewed after a double knee replacement eight years ago. I hear many other such tales on a week-to-week basis. Be advised that some of these procedures are big ones (although minimally invasive approaches are becoming more commonplace) and certainly not risk-free, but they can make a huge difference in quality of life. The day may soon come when joint replacement is accomplished not through titanium alloy, but through stem cell inoculation.

The skin: There’s clearly big business in skin care, and there seem to be hundreds of products that promise to reverse its aging process. Botox provides temporary wrinkle relief and Retin A (tretinoin topical) may help, too, but some people cannot tolerate its drying effects. For most, the clear winner in effectiveness, but only if started early enough, is regular application of sun protection. For those looking for the experimental, a biochemical (a nonflavonoid polyphenol, to be specific) called resveratrol, found in grapes and red wine, has shown promise in reversing cell-damage in skin and other cells. The laboratory evidence for this chemical is alluring, but the actual benefit in practice needs more investigation. For those on statins who might be tempted to try this product, be advised that it may affect the way your body processes your medication. So, talk to your doctor first.

There you go; a quick head to toe on longevity topics. None will help you live to age 300, but that’s probably just fine — I don’t think any of us want to stick around long enough to be subjected to Parton and Bieber singing “Boy Meets Girl.”

Dr. Dustin W. Ballard is an emergency physician at Kaiser Permanente San Rafael and the author of “The Bullet’s Yaw: Reflections on Violence, Healing and an Unforgettable Stranger.” His Medically Clear column appears every third Monday; follow him on Twitter at http://twitter.com/dballard30.